Some things to consider:
Its not necessary, but if you really want to check things, get a compatible OBDII adapter and Forscan software ahead of time so you can scan all the modules for codes, check 12v battery age (below), etc. Search for Forscan on this site (Plus 3 Golfer has lots of informative posts) and check the Forscan site.
Listen for any strange transmission sounds - lots of info on this forum. On the good side, Ford's warranty is for 100k miles (hybrid components) so if you aren't going to drive that much, you'll be covered for quite a while.
Check the 12v battery (its in the back under the floor) for age and proper model. If its not the original type, it likely wasn't replaced by Ford so there's a good chance the 12v battery age parameter wasn't reset (some Ford dealers miss this step as well). If the age isn't reset, the 12v battery won't get charged properly. You can check and reset the age parameter with Forscan.
If possible, make sure all the updates have been done.
Make sure it has a recent inspection and, obviously, check tires, brakes and all the normal used car concerns.
Is it coming from a Ford dealer?
No way I would try to dissuade you. After 194k miles I still love our 2013 SE.